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DEFINITION AND INTRODUCTION The term `leucorrhoea’ signifies abnormal non-haemorrhagic vaginal discharge not caused by neoplasm or other serious organic disease. Normal vaginal secretion is granular and contains desquamated epithelial cells which contain glycogen, cervical mucus and lactobacillus of Doderlein. The reaction of the normal secretion is acid (pH 4.5 to 5.7). Normally the vaginal epithelium is stimulated and built up under the influence of oestrogens and is rich in glycogen. Glycogen is broken down into sugars by the non-bacterial enzymes which in turn are converted into lactic acid by Doderlein’s bacillus. Though in early childhood under the influence of maternal oestrogens secretion may be acid, from early childhood to adolescence oestrogen influence is lacking. During reproductive life there is normal hormonal influence and normal biological condition is maintained. The administration of oestrogens to patients in two age groups with deficient oestrogen stimulus promptly changes the epithelium and secretion to that of normal vagina. ETIOLOGY Interference with the growth and glycogen content of the vaginal epithelium and change in the normal bacterial flora and pH of the vaginal secretions are pre-disposing factors towards vaginal disease and abnormal discharge. The commonest causes of leucorrhoea are normally increased secretion by increased vascularity, passive congestion during puberty, post-menstrual period and pregnancy, chronic retroverted uterus and congestive cardiac failure. Gonococcal, trichomanas and monilial infections may be responsible. Chronic illness, fatigue, malnutrition and emotional disturbances appear to predispose towards persistent and recurrent vaginal discharge. Vulvovaginitis of childhood and senile vaginitis are considered as infections of underdeveloped and atrophic vaginal epithelium associated with altered vaginal physiology and poor resistance to infection. Lesions in the vaginal wall, pelvic infection, uterine cervix lesions, such as acute and chronic endocervicitis and uterine causes such as retained products of conception, neoplasms and polypus, gonococcal, tubercular or senile endometritis and tubal causes such as chronic inflammation, papilloma and carcinoma of the tube may be responsible for leucorrhoea. TREATMENT Vaginal douches destroy normal vaginal flora and if too frequently used can cause chemical irritation. The principles of treatment of any type of leucorrhoea aim at eliminating the causative organism, restoring normal vaginal flora and preventing reinfection in the simplest and most acceptable way to the patient. I have seen in my practice, that in spite of recognised treatment in a large number of cases the symptoms drag on for years together, leading to complete loss of health and neurosis. This problem induced me to try <a href=http://despositobeatrice.soup.io/post/633541389/Lukol-are-usually-safe>Lukol kaufen rezeptfrei</a> tablets in this disorder. THE DRUG Lukol contains Loh Bhasma (iron in its most assimilable form), Withania somnifera, extracts of Saraca indica, Woodfordia floribundi, Symplocos racemosa, Ailanthus excelsa, Leptadenia reticulata and Asparagus recemosus. All the ingredients act synergistically as uterine tonics and nervine sedatives and have a stimulating action on the endometrium and ovarian tissues. Some have astringent action on the mucous membrane and have a sedative effect on the genital tract. MATERIAL AND METHODS This series consists of 75 patients attending the Sonavane Maternity Home with leucorrhoea as their principal complaint. Their ages varied from 13 years to 45 years. As regards marital status, 70 were married while 5 were unmarried. In unmarried patients, menstruation had started 6 to 8 months before the onset of leucorrhoea. One patient was in menopause and had senile vaginitis. Fifty patients were multiparous, 20 sterile and 5 were unmarried girls. The given table gives an idea about the principal as well as side complaints of the patients. The cardio-respiratory and other systems of the patients included in this series were normal. INVESTIGATIONS AND FINDINGS Routine urine and blood examinations were done in all cases. Haemoglobin estimation was done by Sahli’s method. Careful vaginal examinations were done in all married patients before starting the therapy. Findings on vaginal examinations were as follows:— DOSES AND DURATION OF THERAPY Every patient received 2 tablets of Lukol orally thrice daily. The duration of treatment ranged from 1 to 6 weeks. The average duration of treatment was of 3 weeks. Anaemic patients received anti-anaemic drugs along with or prior to Lukol therapy. FOLLOW-UP Vaginal examinations were done every fortnight during the period of therapy and bimonthly during the follow-up period of 6 months. Patients under treatment were interviewed every week and subjective findings were noted down. Clinical results were labelled as excellent when the discharge was completely controlled and there was no recurrence on the cessation of therapy and when accompanying complaints like backache, irregular menses and general debility were corrected. They were considered as fair when there was moderate clinical response and poor when there was little or no response. OBSERVATIONS Uncomplicated cases of leucorrhoea of less than two months’ duration usually responded excellently within a fortnight of Lukol therapy. Chronic cases, however, needed treatment for 3 to 6 weeks. All unmarried patients were completely relieved. Improvement in the general condition was noticed in all the treated cases. In patients with vaginitis, response to Lukol at the end of the first week’s therapy was not satisfactory. During the subsequent weeks, on adding antibiotics and local therapy with pessaries results were gratifying. Endocervicitis was better in 4 cases. Erosion in 6 cases showed healing while other 3 cases needed cauterisation. Tubo-ovarian thickenings and fixity of uterus remained unaffected by Lukol therapy. Seventy cases were regular in treatment as well as follow-up after initial improvement they have been omitted from the series. The following table gives the results of the Lukol therapy:SIDE-EFFECTS OR TOXIC REACTIONS In this series of 70 cases Lukol tablets were administered orally in doses of 2 t.d.s. for an average duration of 3 weeks, yet not a single side effect or sign of toxicity was observed. All patients tolerated the drug excellently. SUMMARY AND CONCLUSIONS In our series of 70 cases of leucorrhoea oral Lukol therapy in doses of 2 t.d.s. daily rendered excellent results in 71% cases while 16% cases showed poor response, 13% cases showed moderate improvement. Lukol did not produce any toxic reaction or untoward side-effect. Considering its efficacy and safety, it can well be acclaimed as a promising remedy in the management of leucorrhoea. |
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 ICI >> Lukol kaufen
(aaronallen,26/10/2015) |